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A single intraperitoneal injection of nicotine increased phosphorylated extracellular regulated kinase (pERK) in the CeA 20 min after drug administration (Valjent et al., 2004), however a study of voluntary nicotine drinking found no increase in amygdala pERK after an acute (1.3 h) drinking session and only saw a significant increase in amygdala pERK after chronic (2830 d) drinking (Brunzell et al., 2003)

In most films where smoking is depicted, there is no mention of addiction, disease, or death

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