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297,298 In patients with hyperuricemia, elevated serum levels of high-sensitivity C-reactive protein (hs-CRP) are closely linked to inflammation and oxidative stress, which may exacerbate hypertension

The rash typically is seen on the sides and webs of the fingers, the wrist, elbows, genitals, and buttock

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Furthermore, complexes formed between Smurf2 and Smad7 target the activated TGF- type I receptor for ubiquitination and degradation (85)