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The H 2 O was added to the NMR sample to enable better resolution of the OH proton peaks of 1a-d from an overlapping resonance

Smokers account for one-fifth of all deaths from heart disease, and a 70% higher death rate from coronary heart disease than non-smokers

Callahan-Lyon, P

Based on FDA's careful review of the scientific literature on the health risks associated with cigarette smoking, evaluation of the public's general awareness and knowledge of those health risks, and assessment of the Agency's own consumer research on potential revised warning statements, FDA determined there is sufficient support to propose adjusting some of the text of the TCA statements, as authorized by section 4(d) of the FCLAA (as amended by section 202(b) of the Tobacco Control Act)