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if there is any inter-current illness that would, in the judgment of the investigators, affect outcome measures to a significant degree

The adhesives on gummed tapes must be adequately activated before application and firmly applied with the tape extending at least 3 inches over the adjoining side of the box

Pathophysiologic mechanisms

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But the fact that the tobacco industry had worked as a cartel to prevent the development of healthier, less addictive cigarettes, as well as suppressing research into the harms that their products had on smokers, was a recurring issue in the case