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These drugs were initially identified via a network targeting strategy: senescent cells accumulate with age or disease and upregulate anti-apoptotic pathways (SCAPs) such as B-cell lymphoma-2/extra large (BCL-2/BCL-XL), phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), hypoxia-inducible factor-1 (HIF-1), and receptor/tyrosine kinase-dependent pathways, counteracting the pro-apoptotic effects of the senescence-associated secretory phenotype (SASP) (152, 153)

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