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In conducting nicotine experiments on pregnant humans the authors effectively ignored scores of animal studies finding that nicotine during pregnancy causes what the authors term "serious detrimental effects." As reviewers, three of the study's authors, including the lead author, were involved in producing a 2005 UK guidance advocating NRT use by pregnant smokers

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The FDA says nicotine products are highly addictive and are not risk-free even for adults, while nicotine can harm developing brains

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