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[143] Similarly, accumbal G9a hyperexpression results in markedly increased histone 3 lysine residue 9 dimethylation (H3K9me2) and blocks the induction of FosB-mediated neural and behavioral plasticity by chronic drug use, [sources 12] which occurs via H3K9me2-mediated repression of transcription factors for FosB and H3K9me2-mediated repression of various FosB transcriptional targets (e.g., CDK5)

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7 The symptoms of COPD are induced and exacerbated by exposure to cigarette smoke, 8 which causes inflammation and oxidative stress

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Currently, this is the only ICD-10 code specific to this problem, so you will be relying on this for such cases