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around 2007 with the promise of providing smokers with a less harmful alternative to smoking traditional tobacco cigarettes

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Current smokers were found to have lower plasma TPO-Ab levels when compared to exsmokers in some studies,[] although a few did not find such association.[] Even studies on patients of Graves' hyperthyroidism report a lower level of TPO-Ab in current smokers compared to nonsmokers,[] prompting authors to postulates that smoking may protect against Hashimoto's hypothyroidism by reducing TPO-Abs, while at the same time elevating the risk for Grave's hyperthyroidism.[] The protection against autoimmune hypothyroidism may not be complete, an increase in serum thiocyanate concentration from smoking may also contribute to the development of hypothyroidism in patients with Hashimoto's thyroiditis, rather than protecting against it.[] Smoking has been found to affect other autoimmune thyroiditis in inconsistent manner

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