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The letter went so far as to claim that the paucity of evidence of serious harm to e-cigarette users since they were first marketed in 2006, with millions sold, was proof in itself.[xxxii] We are here obliged to recall the aphorism, often attributed to astrophysicists Martin Rees or Carl Sagan, that "absence of evidence is not evidence of absence".[xxxiii] Absence of evidence is not evidence of absence

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