When the CLO dose was reduced to 500 mg/day, the confusion disappeared within 1 week and the plasma CLO concentration returned to the pre-smoking cessation level ( In the present study, it was also found that before smoking cessation, only 9.4% patients had plasma CLO concentrations above the upper limit of the therapeutic reference range, i.e., 600 ng/mL, and no patient had plasma CLO concentrations higher than the laboratory alert concentration of 1,000 ng/mL
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