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The patient also presented with skin hyperextensibility, joint hypermobility, and Gorlin sign (ability to reach the nose with the tip of the tongue) (Fig

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Finally, the animals were euthanized at the end of the experiment under deep anesthesia by intraperitoneal injection of ketamine/xylazine followed by intravenous injection of KCL (149 mg/ml, 0.5 ml/250 gm body weight) to stop the hearts in a relatively diastolic or relaxed state

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