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Connecticut ($3.90), Rhode Island ($3.75), and Massachusetts ($3.51) follow closely behind

They often create: Reduced airflow and stiff drag Blunted flavor quality Minimal visual indication of trapped tar Ineffective filtration of micro-particles and combustion residuetar's result, many smokers abdon't filters entirely or use low-grade products that offer little real protection or benefit

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Moreover, telomerase reverse transcriptase (TERT) promoter mutations, strongly associated with smoking, have been implicated in hepatocarcinogenesis and tumor progression [41,42,43]