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Although not very common, they are generally caused by the misuse or improper care of the device
Moreover, given the paucity of reliable data of nicotine dose, we identified the human-relevant physiological concentration of nicotine by examining the serum level of cotinine, the primary metabolite of nicotine, and a biomarker of tobacco smoke exposure, in mice injected with 2 mg/kg of nicotine in time-dependent manner and found that the cotinine level is comparable with adult smokers serum cotinine level compared to never-smokers as previously described 61 (Supplementary Fig
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