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Molecular mechanisms, regulatory pathways, and therapeutic implications

While Nicotine is the main addictive substance in tobacco smoke, many major smoking-related diseases are associated with toxicants produced by combustion, including carbon monoxide and carcinogenic compounds in smoke

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The product claims categories were informed by prior research on marketing for nicotine pouches and smokeless tobacco products3 16 17: alternative to other tobacco products, ability to use anywhere, spit-free, smoke-free and product does not contain tobacco leaf

The brands in question are from the companies named in the July Tisa report: Amalgamated Tobacco Manufacturers, Best Tobacco Company, Carnilinx Tobacco Company, Gold Leaf Tobacco Corporation, Pacific Cigarette Company and "any regional tobacco manufacturer/distributor marketing below the minimum tax portion owed to Sars [the SA Revenue Service]"