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Classic EDS is inherited in an autosomal dominant manner and is caused by mutations in COL5A1 or COL5A2, which encode the alpha-1 and alpha-2 chains, respectively, of collagen type V.1 The disease is characterized by skin hyperextensibility, joint hypermobility and associated complications (luxations, pain, early osteoarthritis), and other clinical characteristics that are reviewed in a recent international consensus paper.1 Dermatologic manifestations of classic EDS include skin hyperextensibility and abnormal scarring, which results the formation of atrophic scars with a cigarette-paper-like appearance

surgeon general's report came out about the health effects of smoking

It's extremely unstable, so the third atom of oxygen can easily detach from the molecule and attach to other molecules

Retrieved 25 January 2013.

However, It cannot tell the difference between a threat to our sense of ourselves (our identities) and our physical bodies - hence all the resistance