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British American Tobacco PLC, Altria Group Inc., Japan Tobacco International, ITC Limited, Philip Morris Products SA are playing a dominating role in the global cigarette market

Given the consistent presence of extreme T max values across multiple studies, we have adopted the standard practice of using nonparametric methods, such as reporting medians for T max , to provide a more robust and accurate representation of the data

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The abnormal cells are local (N0) and not in other organs (M0)