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North Korea's anti-smoking drives became a regular occurrence after it became a signatory to the WHO Framework Convention on Tobacco Control, which it ratified in 2005

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Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats

This hypothesis was popularized in the 80sat the peak of the War on Drugs and the Just Say No campaign