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Yiyang Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Step-by-Step Usage Instructions Place the lozenge: Position between cheek and gum, not under the tongue Allow dissolution: Let it dissolve slowly over 20-30 minutes Rotate position: Move the lozenge occasionally to prevent irritation Avoid swallowing: Dont chew or swallow the lozenge whole Limit food/drink: Avoid eating or drinking 15 minutes before and during use Nicotine gum users: When using nicotine chewing gum, chew the gum until you notice a strong taste, then 'park' it between your gum and cheek

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