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Nicotine, the main active ingredient in tobacco, initially acts as a stimulant by triggering the release of adrenaline and dopamine, which: Increase heart rate Raise blood pressure Stimulate brain activity This is why smokers often experience an initial rush or sense of alertness and pleasure after using tobacco

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These are key discoveries that advance our understanding of the neurological bases of smoking and drinking and also provide new evidence on the different neurological mechanisms that are related to these two types of human addictive behavior, smoking and drinking, and these advances have implications for prevention and treatment of these two substance use. The paper Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. was published today, 8th January 2019 in eLife journal

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