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In AD, this balance is frequently disrupted, leading to microbial dysbiosis that not only exacerbates local inflammation but also serves as a potential trigger for aberrant activation of the mast cellneuron axis ( Under conditions of barrier disruption or dysbiosis, opportunistic pathogens, most notably Staphylococcus aureus , can overcolonize the skin ( Staphylococcus aureus induces nonIgE-dependent degranulation via a Ca + influxPI3K signaling pathway, and in vivo provokes vascular leakage and eczematous skin lesions

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The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease

The move was declared "political suicide" for the city's Governor, Powes Parkop, who spearheaded its implementation