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If the assumption of equal variances was violated, the Welch test was used, which provides a more robust alternative to the standard t-test under heteroscedasticity

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*Correspondence: Zhenhua Dai, [email protected] Specialty section: This article was submitted to Alloimmunity and Transplantation, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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