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Use of nicotine is also associated with a number of side effects on organs and organ systems, including: Increased risk of blood clots Atherosclerosis Peptic ulcers Changes in heart rhythm Lung spasms Nicotine can also alter or harm the development of the brain in children and teens

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It also contributes in filling the gap of independent measurements of illicit cigarette trade in developing countries, as most of research in this area has been done for developed countries,17 only a few have been done for developing countries,1820 and there were no previous independent estimations for Colombia