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Drug and Alcohol Dependence , 201 , 8593

While there is a general consensus that high-quality epidemiological studies backed by solid toxicology and other mechanistic biological evidence provide the strongest basis for making firm inferences regarding causality, that simply does not exist for these devices

The key factors are: Total daily caffeine intake: Too much caffeine from any source can lead to jitteriness, insomnia, rapid heartbeat, or anxiety

It is estimated that over one million smokers in the UK participate in NSD and an estimated 40,000 people stop smoking each year as a result

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